genome sequencing

New publications in health economics and genomics 5th October 2022

James Buchanan Weekly new publication alerts , , , , , , , ,

Nine publications from the past two weeks:

  • Tools for the Economic Evaluation of Precision Medicine: A Scoping Review of Frameworks for Valuing Heterogeneity-Informed Decisions | link
  • Reduced resource utilization with early use of next-generation sequencing in rare genetic diseases in an Asian cohort | link
  • Resource allocation in genetic and genomic medicine | link (the rest of this Special Issue is available here)
  • Correspondence on “Cost-effectiveness of exome and genome sequencing for children with rare and undiagnosed conditions” by Lavelle et al | link
  • Response to Grosse and Gudgeon | link
  • Economic Aspects in Precision Medicine and Pharmacogenomics | link
  • Economic evaluation of using polygenic risk score to guide risk screening and interventions for the prevention of type 2 diabetes in individuals with high overall baseline risk | link
  • Epistemic justice, African values and feedback of findings in African genomics research | link
  • Reduced resource utilization with early use of next-generation sequencing in rare genetic diseases in an Asian cohort | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

Journal Special Issue published on Resource Allocation in Genetic and Genomic Medicine

James Buchanan Other , , , , , , , , ,

I’m pleased to announce the publication of a Special Issue of the Journal of Community Genetics, which I edited with Ilias Goranitis and Ingrid Slade.

https://link.springer.com/journal/12687/volumes-and-issues/13-5

Titled: “Resource Allocation in Genetic and Genomic Medicine”, this Special Issue features 6 papers and an editorial, and grew out of a conference we organised at HERC in 2018 with the Centre for Personalised Medicine and the Ethox Centre, both in Oxford, titled “Resource Allocation in Personalised Medicine: Evaluation, Translation and Ethics”.

You can view presentations from this conference here: https://cpm.well.ox.ac.uk/term/resource-allocation-ethics-and-market

Although the Special Issue has now been published, a virtual collection remains open to receive further articles on this topic. You can access this virtual collection here: https://link.springer.com/collections/hdbhhddibh

Vacancy for researcher in health economics and genomics

James Buchanan Other , , , , , , , ,

HERC are currently advertising vacancies for two researchers in health economics (https://www.herc.ox.ac.uk/about/work-with-us).

These researchers will work across multiple projects, one of which is a project with me, titled: “Psychometric assessment of EQ-5D-5L, EQ-HWB and EQ-5D-Y-5L in rare genetic diseases”.

Genomic testing is starting to be translated into clinical practice for people with rare genetic diseases. In England, the National Health Service has recently launched a new Genomic Medicine Service. However, data on the outcomes of genomic testing is sparse, and there is uncertainty regarding the appropriate outcome measures to use. Data on the use of both established and new instruments, such as the EQ-5D-5L, EQ-HWB and EQ-5D-Y-5L, would inform more robust health technology assessment decisions in this context. This work will involve assessing the psychometric properties of the EQ-5D-5L, EQ-HWB, and EQ-5D-Y-5L instruments in adult patients and parents of children with lived experience of rare genetic diseases using mixed methods. Recruitment for this study will take place in both England and Australia, in conjunction with collaborators at the University of Melbourne, lead by Ilias Goranitis.

The closing date for applications is 12.00 noon on Thursday 03 November 2022.

If you have any questions, or would like to discuss the vacancy, please email me at james.buchanan@dph.ox.ac.uk

New publications in health economics and genomics 13th September 2022

James Buchanan Weekly new publication alerts , , , , , , , ,

Two publications from the past week:

  • Population genomic screening of young adults for familial hypercholesterolaemia: a cost-effectiveness analysis | link
  • Early cost-utility analysis of genetically-guided therapy for patients with drug-resistant epilepsy | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 7th September 2022

James Buchanan Weekly new publication alerts , , , , , , , ,

One publication from the past week:

  • Managing the introduction of genomic applications into the National Health Service: A special challenge for health technology assessment in Italy | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 30th August 2022

James Buchanan Weekly new publication alerts , , , , , , , ,

Three publications from the past week:

  • Integrating the Biology of Cardiovascular Disease into the Epidemiology of Economic Decision Modelling via Mendelian Randomisation | link
  • Health technology assessment of whole genome sequencing in the diagnosis of genetic disorders: a scoping review of the literature | link
  • The Potential Value-Based Price of a Multi-Cancer Early Detection Genomic Blood Test to Complement Current Single Cancer Screening in the USA | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 23rd August 2022

James Buchanan Weekly new publication alerts , , , , , , , ,

Four publications from the past week:

  • Cost-Effectiveness of Exome Sequencing versus Targeted Gene Panels for Prenatal Diagnosis of Fetal Effusions and Non-Immune Hydrops Fetalis | link
  • Preferences for a polygenic test to estimate cancer risk in a general Australian population | link
  • Cost-Effectiveness and Budget Impact of Future Developments With Whole-Genome Sequencing for Patients With Lung Cancer | link
  • Cost-effectiveness of molecularly matched off-label therapies for end-stage cancer – the MetAction precision medicine study | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 16th August 2022

James Buchanan Weekly new publication alerts , , , , , , , ,

Four publications from the past week:

  • Economic evaluation of genomic/genetic tests: a review and future directions | link
  • Whole exome and genome sequencing in mendelian disorders: a diagnostic and health economic analysis | link
  • Cost-effectiveness of population-wide genomic screening for familial hypercholesterolemia in the United States | link
  • Real-world economic evaluation of prospective rapid whole-genome sequencing compared to a matched retrospective cohort of critically ill pediatric patients in the United States | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 9th August 2022

James Buchanan Weekly new publication alerts , , , , , , , ,

One publication from the past week:

  • Is faster better? An economic evaluation of rapid and ultra-rapid genomic testing in critically ill infants and children | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 19th July 2022

James Buchanan Weekly new publication alerts , , , , , , , ,

Three publications from the past week:

  • Cost-effectiveness frameworks for comparing genome and exome sequencing versus conventional diagnostic pathways: A scoping review and recommended methods | link
  • ‘Diagnostic shock’: the impact of results from ultrarapid genomic sequencing of critically unwell children on aspects of family functioning | link
  • Challenges of Conducting Value Assessment for Comprehensive Genomic Profiling | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.