New publications in health economics and genomics 27th October 2020

Five publications from the past week:

  • Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study | link
  • Health outcomes, utility and costs of returning incidental results from genomic sequencing in a Canadian cancer population: protocol for a mixed-methods randomised controlled trial | link
  • Measuring clinical utility in the context of genetic testing: a scoping review | link
  • Expanding Use of Clinical Genome Sequencing and the Need for More Data on Implementation | link
  • Implementing Interventions with Varying Marginal Cost-Effectiveness: An Application in Precision Medicine | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics!

New publications in health economics and genomics 20th October 2020

One publication from the past week:

  • Evaluating the economic effects of genomic sequencing of pathogens to prioritise hospital patients competing for isolation beds | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics!

New DPhil (PhD) opportunity in health economics and genomics

We have just advertised a new DPhil (PhD) position here at the Health Economics Research Centre in the area of health economics and genomics. The proposed start date is October 2021 and the full title is “Valuing the outcomes associated with genome sequencing in economic evaluations”. The student will be supervised by myself and Professor Sarah Wordsworth.

The primary aim of this project is to evaluate existing instruments used to generate quality of life weights for use in extra-welfarist economic evaluations, in terms of their capacity to capture all impacts of genome sequencing on patient wellbeing. Such instruments will include the EQ-5D-5L, the SF-36 and ICECAP capability measures. We expect the student will: 

  • Critically appraise the theoretical capacity of existing instruments to capture the impacts of genome sequencing;
  • Review the current use of these instruments in this context;
  • Generate new data on the use of these instruments in patients undergoing genome sequencing;
  • Identify instruments that effectively value the outcomes associated with genome sequencing;
  • Describe the characteristics of any new instruments that may be required.

The deadline for applications is 1200 noon UK time on Friday 8th January 2021.

If anybody has any questions about this project then please don’t hesitate to get in touch by email (james.buchanan@dph.ox.ac.uk). Please also share the details of this project with anybody who you think might be interested.

Full details of this project are available here.

New publications in health economics and genomics 6th October 2020

No publications last week or this week. I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics!

New publications in health economics and genomics 22nd September 2020

Three publications from the past week:

  • A three-year follow-up study evaluating clinical utility of exome sequencing and diagnostic potential of reanalysis | link
  • Clinical Utilization, Utility, and Reimbursement for Expanded Genomic Panel Testing in Adult Oncology | link
  • Cost-effectiveness analysis comparing companion diagnostic tests for EGFR, ALK, and ROS1 versus next-generation sequencing (NGS) in advanced adenocarcinoma lung cancer patients | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics!

New publications in health economics and genomics 8th September 2020

Two publications from the last week:

  • Efficacy and economics of targeted panel versus whole exome sequencing in 878 patients with suspected primary immunodeficiency | link
  • Genomic Testing for Relapsed and Refractory Lymphoid Cancers: Understanding Patient Values | link

I’m happy to share any other publications from this week that I’ve missed – just let me know.

New publications in health economics and genomics 1st September 2020

One publication from the last week:

  • The value of genomic sequencing in complex pediatric neurological disorders: a discrete choice experiment | link

I’m happy to share any other publications from this week that I’ve missed – just let me know.

New publications in health economics and genomics 25th August 2020

Two publications from the last week:

  • Clinical and Economic Outcomes of Genome Sequencing Availability on Containing a Hospital Outbreak of Resistant Escherichia coli in Australia | link
  • Health-care practitioners’ preferences for the return of secondary findings from next-generation sequencing: a discrete choice experiment | link

I’m happy to share any other publications from this week that I’ve missed – just let me know.

New publications in health economics and genomics 18th August 2020

Two publications from the last week:

  • Provider preferences for resolving uncertainty and avoiding harms in precision medicine: a discrete choice experiment | link
  • A cost-effectiveness analysis of genomic sequencing in a prospective versus historical cohort of complex pediatric patients | link

I’m happy to share any other publications from this week that I’ve missed – just let me know.

New publications in health economics and genomics 11th August 2020

Two publications from the last two weeks:

  • Clinical and Economic Value of Genetic Sequencing for Personalized Therapy in Non-small-cell Lung Cancer | link
  • PARC report: a health-systems focus on reimbursement and patient access to pharmacogenomics testing | link

I’m happy to share any other publications from this week that I’ve missed – just let me know.