New publications in health economics and genomics 4th May 2021

One publication from the past week:

  • Early technology assessment of using whole genome sequencing in personalised oncology | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

Translating sequencing into clinical practice in Africa: a health economics perspective

A couple of weeks ago I presented at the 17th H3Africa Consortium Meeting on translating genome and exome sequencing into clinical practice in Africa.

I’ve now uploaded a video of my presentation, in case this is of interest to anybody.

The full abstract for this session was:

Research into genomics in Africa has progressed significantly over the past 10-15 years. In the coming years, attention will increasingly turn to the translation of genomic tests into routine clinical practice. This will naturally require a high quality Africa-specific scientific and clinical evidence base, considerable investment in infrastructure, and new and evolving partnerships between academia, government, health systems, industry, and patients and their families. A crucial component of the evidence base to support translation is data on the health economics of sequencing in an African context.

In this presentation I will provide a health economics perspective on the next steps in this translational journey. This perspective is informed by my experience undertaking health economics analyses as part of the Genomics England 100,000 Genomes Project, and collaborating on health economics studies in other countries translating genomics into clinical practice, including the USA, Canada, Australia and France.

I will describe the health economic evidence that is likely to be required in an African context to support the more widespread use of sequencing technologies, and I will summarise the challenges that may arise when generating this evidence (such as identifying clinically meaningful outcomes and working with big data). Importantly, I will also highlight the many opportunities for African health economists working in this field, who are well placed to address research questions that researchers in high-income countries are yet to tackle. These include investigations into the impact of genetic diversity on the costs and outcomes of sequencing, the cost-effectiveness of introducing different testing models in different settings, and the value of screening for variants that are rare in European populations but common in African populations. I will end by outlining potential next steps, including the need to embed collection of health economic data in new biobanks and large scale sequencing studies at an early stage.

New publications in health economics and genomics 27th April 2021

Two publications from the past week:

  • Toward the diagnosis of rare childhood genetic diseases: what do parents value most? | link
  • Rapid whole genome sequencing impacts care and resource utilization in infants with congenital heart disease | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 20th April 2021

Two publications from the past week:

  • Guidance for the Harmonisation and Improvement of Economic Evaluations of Personalised Medicine | link
  • Micro-costing diagnostics in oncology: from single-gene testing to whole genome sequencing | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New iHEA Special Interest Group on the Economics of Genomics and Precision Medicine (Econ-Omics)

I’m pleased to report that the International Health Economics Association (iHEA) have recently approved a new Special Interest Group (SIG) focusing on the Economics of Genomics and Precision Medicine (Econ-Omics). I am one of the three founders and lead conveners of this SIG, alongside Ilias Goranitis and Deirdre Weymann.

The aim of the Econ-Omics SIG is to bring together interested researchers around the world to build health economics capacity, advance methods, and facilitate communication and generation of the health economics evidence required to underpin the appropriate widespread use of genomic information in clinical practice. You can find more information about this SIG on our webpage, and you can stay up to date with our news and activities via our Twitter account here.

We have planned a number of exciting initiatives and activities and we’re looking forward to moving these forward over the coming months. These include:

  • An Econ-Omics blog and a quarterly newsletter
  • An annual symposium
  • Coordination of organised sessions at the iHEA Congress
  • A regular webinar series
  • Investigating opportunities for cross-country and cross-regional mentoring of ECRs
  • Sharing of teaching materials related to genomics and precision medicine

Membership is open to all iHEA members who are interested in the economics of genomics and precision medicine. You can join the SIG by logging into the iHEA website, selecting the “groups” section and clicking “request to join” the Economics of Genomics and Precision Medicine SIG (Econ-Omics). We particularly encourage expressions of interest to support the SIG in a convener role – please get in touch if this is of interest.

New publications in health economics and genomics 13th April 2021

One publication from the past week:

  • Using molecular testing and whole-genome sequencing for tuberculosis diagnosis in a low-burden setting: a cost-effectiveness analysis using transmission-dynamic modelling | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

An additional note for this week only: I’ve now been publishing these updates for a year. I find the process useful as it forces me to make time each week to keep up with the literature. I hope the updates are useful for others too. If the updates could be tweaked in any way to be more helpful going forward, please let me know (different frequency or weekday, more/less info for each publication etc.).

New publications in health economics and genomics 6th April 2021

Two publications from the past week:

  • Preferences and values for rapid genomic testing in critically ill infants and children: a discrete choice experiment | link
  • Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 30th March 2021

Three publications from the past week:

  • Utility of Genetic Testing from the Perspective of Parents/Caregivers: A Scoping Review | link
  • Universal newborn genetic screening for pediatric cancer predisposition syndromes: model-based insights | link
  • Whole exome sequencing in molecular diagnostics of cancer decreases over time: evidence from a cost analysis in the French setting | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 23rd March 2021

Four publications from the past week:

  • Economic Impact of Coverage Expansion for Non-invasive Prenatal Testing Through a Performance-Based Risk-Sharing Agreement | link
  • Cost of whole genome sequencing for non-typhoidal Salmonella enterica | link
  • Comparison of Decision Modeling Approaches for Health Technology and Policy Evaluation | link
  • Family-level impact of genetic testing: integrating health economics and ethical, legal, and social implications | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.

New publications in health economics and genomics 16th March 2021

Two publications from the past week:

  • Comprehensive Genomic Profiling for Non-Small-Cell Lung Cancer: Health and Budget Impact | link
  • The ethics of resource allocation in translational genomic medicine | link

I’m happy to share any other publications from this week that I’ve missed – just let me know. I publish these updates weekly, on a Tuesday, but only if I’ve seen relevant publications. If you don’t see an update on a Tuesday, assume it has been a quiet week for publications in health economics and genomics.